Energy balance in critical illness

Energy balance in critical illness.

Energy balance is the difference between energy consumed and total energy expended. Over a given period of time it expresses how much the body stores of fat, carbohydrate and protein will change. For the critically-ill patient, who characteristically exhibits raised energy expenditure and proteolysis of skeletal muscle, energy balance information is valuable because underfeeding or overfeeding ...

Best timing for energy provision during critical illness

Lactate in critical illness

Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in ...

CritiCal illness in pregnanCy

Critical illness in pregnancy increases maternal and fetal morbidity and mortality. The critical illness can be related to pregnancy per se, or can be secondary to a concurrent medical illness. Early identification and appropriate management results in good outcomes with a short ICU stay. Late identification and delayed therapy results in poor maternal & fetal outcomes with development of multi...

Leptin-promoted cilia assembly is critical for normal energy balance.

The majority of mammalian cells have nonmotile primary cilia on their surface that act as antenna-like sensory organelles. Genetic defects that result in ciliary dysfunction are associated with obesity in humans and rodents, which suggests that functional cilia are important for controlling energy balance. Here we demonstrated that neuronal cilia lengths were selectively reduced in hypothalami ...